Indwara z'umutima-damura, nizo zitera impfu z'indwara zitandura, ahanini ni indwara ziterwa no gusaza.Hamwe no kwiyongera kwimyaka, umutima, nkurwego ruvoma amaraso, uzasaza, kandi ubushobozi bwayo bwo kuruhuka no kwandura bizagabanuka, kandi bizagenda buhoro buhoro bidashobora kuvoma amaraso mumubiri wose, amaherezo bikazatera kunanirwa kumutima. abarwayi kandi bigira ingaruka zikomeye mubuzima bwiza bwabantu.
Gusaza k'umutima kurangwa no kugabanuka k'umutima (imikorere y'umutima), bizajyana no kugabanuka kwa poroteyine nyinshi no guhindura poroteyine nyuma yo guhindura.
SS-31 peptide ni inhibitori ya cardiolipine peroxidase hamwe na mitochondrial yibasira peptide.Irashobora kunoza imikorere ya ventricle ibumoso na mitochondria.SS-31 peptide irashobora kugabanya imikorere mibi ya mitochondrial no kwangirika kwa okiside mumyanya mikorere ya trabecular meshwork.Irashobora gukumira iHTM na GTM (3) ingirabuzimafatizo zidakira ziterwa na H2O2.
SS-31 ni mitochondrial yibasira ibintu birwanya gusaza, byagaragaye ko bifite akamaro mukugarura imikorere yumutima yimbeba zishaje.Ni tetrapeptide ya sintetike ihujwe na mitochondrial imbere yimbere, ishobora kunoza imikorere ya mito-iyambere, kugabanya umusaruro wubwoko bwa ogisijeni ya ROS ikora, kugabanya urwego rwibintu bitera umuriro kandi byongera cyane cyane imikorere ya diastolique yumutima.
Ubwa mbere, ugereranije imbeba zikiri nto nimbeba zishaje, abahanga basanze ubwinshi bwa poroteyine za mitochondial ziterwa cyane cyane no gusaza, harimo inzira yo kwanduza ibimenyetso bya mitochondial, proteyine zijyanye n'inzira ya fosifori yo mu bwoko bwa okiside itanga ingufu, hamwe na poroteyine zijyanye n'inzira yo gukwirakwiza ibimenyetso bya SIRT bijyanye n'ingufu. metabolism muri mitochondria.Byongeye kandi, poroteyine za ngombwa troponine na tropomyosine, zihuza mu buryo butaziguye no kugabanuka kwa myocardial, na byo bigaragara ko byatewe no gusaza.Ibi bifitanye isano ya hafi nimikorere yumutima.Icya kabiri, iyo usuzumye ingaruka zokuvura SS-31, abashakashatsi basanze ubwinshi bwa poroteyine yimbeba zishaje zavuwe zisa nkaho zidahuye niz'itsinda rito, ariko bose bagaragaje ko inzira yo kudakora hamwe no gusaza, nka poroteyine ubwinshi bwa acide ya tricarboxylic, inzira nyamukuru yo kubyara ingufu mumubiri, yagaruye rwose murwego runini, bigatuma imbeba zishaje zikiri nto.Ibi bivuze ko SS-31 ifite akamaro kanini muguhindura imbaraga za metabolism ziterwa no gusaza k'umutima.Ubushakashatsi ku bwinshi bwa poroteyine bwarangiye, hanyuma abashakashatsi berekeza ibitekerezo ku mpinduka zahinduwe na poroteyine nyuma y’ubuhinduzi mu gihe cyo gusaza, maze bahitamo cyane cyane ibyahinduwe nyuma y’ubuhinduzi muri poroteyine, bifitanye isano cyane n’umutima. Guhindura.Hashobora kubaho impinduka ebyiri muguhindura acetylation.Ubwa mbere, kubera ko acetylation ya proteine ya mitochondrial iziyongera uko imyaka igenda ishira, bikavamo imikorere mibi ya mitochondial, kandi mitochondial yumutima iri hejuru cyane, kubwibyo umutima wose ushobora kuba ufite kwirundanya cyane kwa acetylation mugihe imikorere yumutima igabanuka;Icya kabiri, hazabaho gutakaza acetylation isanzwe yibisigisigi byihariye mugihe cyo gusaza, bizatera kunanirwa gukina imikorere isanzwe.Abashakashatsi bakungahaye kuri peptide ya acetile mu mutima (ushobora kumvikana gusa nk'uduce duto dukoreshwa mu gukora poroteyine).Haracyariho itandukaniro muburyo bwa acetylation ya proteine yumutima hagati yitsinda rito nitsinda rishaje, ariko ntibigaragara nkubwinshi bwa poroteyine.Hanyuma kandi barushijeho gukora ubushakashatsi kuri poroteyine iyi mpinduka muburyo bwa acetylation ishobora kuba yihariye.Hanyuma, abashakashatsi bongeye guhuza ubushobozi bwa systolique na diastolique yumutima basanga ibibanza 14 bya acetylation bijyanye nubushobozi bwa diastolique yumutima, kandi byose byari bifitanye isano mbi.Muri icyo gihe, imbuga ebyiri zijyanye no kwandura umutima nazo zabonetse.Ibi bivuze ko guhindura amasezerano mugihe cyo gusaza bishobora kugengwa na acetylation ya proteine yumutima.
Turi polypeptide mu Bushinwa, dufite uburambe bwimyaka myinshi mukubyara umusaruro wa polypeptide.Hangzhou Taijia Biotech Co., Ltd. ni uruganda rukora ibikoresho bya polypeptide yabigize umwuga, rushobora gutanga ibihumbi icumi by’ibikoresho fatizo bya polypeptide kandi birashobora no gutegurwa ukurikije ibikenewe.Ubwiza bwibicuruzwa bya polypeptide nibyiza, kandi ubuziranenge bushobora kugera kuri 98%, byamenyekanye nabakoresha kwisi yose. Murakaza neza kutugisha inama.
