Retatrutide ni peptide yubushakashatsi bwakozwe kugirango igere icyarimwe gukora reseptor eshatu zingenzi zigira uruhare muri glucose homeostasis no kuringaniza ingufu: reseptor ya glucagon (GCGR), reseptor ya glucose iterwa na glucose ya reseptor (GIPR) hamwe na glucagon imeze nka peptide-1 (GLP- 1R) (Finan et al., 2023, Ikinyamakuru cy’ubuvuzi cya New England).Mu kwibasira aba reseptors, retatrutide yigana ingaruka ziterwa na ligandes zabo, glucagon, GIP na GLP-1, ni imisemburo igenga glucose metabolism hamwe nuburemere bwumubiri mubice bitandukanye, nka pancreas, umwijima, ubwonko, tissue adipose na gastrointestinal tract (Drucker, 2023, Kamere).
Bitandukanye na endogenous ligands, ifite igice cyigihe gito cyubuzima, kwangirika byihuse na dipeptidyl peptidase-4 (DPP-4) enzyme ningaruka mbi zitifuzwa, nka hypoglycemia na isesemi (Drucker, 2023, Kamere), retatrutide yarakozwe kugirango itsinde ibi aho bigarukira.Retatrutide ni peptide ya fusion igizwe nurutonde rwa glucagon rwahinduwe ruhujwe nurutonde rwa GLP-1 rwahinduwe binyuze murwego rwa GIP (Finan et al., 2023, Ikinyamakuru cyitwa New England Journal of Medicine).Ihinduka ririmo insimburangingo ya aside amine no gusiba byongera ituze, imbaraga noguhitamo peptide kubakira batatu (Finan et al., 2023, Ikinyamakuru cyitwa New England Journal of Medicine).
Retatrutide yerekanye imiti idasanzwe ya farumasi nuburyo bwiza bwo kuvura umubyibuho ukabije na diyabete yo mu bwoko bwa 2 mubushakashatsi bwibanze nubuvuzi.Mu ngero z’inyamanswa zifite umubyibuho ukabije na diyabete, retatrutide yerekanye ingaruka zisumba izindi mu kugabanya urugero rwa glucose yamaraso, gutera insuline gusohora, guhagarika imisemburo ya glucagon, gutinda gusohora gastrica, kugabanya ibiryo ndetse nuburemere bwumubiri ugereranije na agoniste umwe cyangwa ibiri ya reseptor eshatu (Gault et al., 2023, Diyabete, Umubyibuho ukabije na Metabolism; Coskun n'abandi, 2023a, Metabolism ya Molecular).Retatrutide yanateje imbere imiterere ya lipide, imikorere yumwijima, gutwika hamwe nu bipimo byumutima nimiyoboro y'amaraso muri aya matungo (Gault et al., 2023, Diyabete, Umubyibuho ukabije na Metabolism; Coskun et al., 2023a, Molecular Metabolism).
Mu bigeragezo by’amavuriro byabantu, retatrutide yerekanye kandi ibisubizo bitanga umusaruro kubarwayi bafite umubyibuho ukabije na diyabete.Retatrutide yarihanganiye neza kandi yerekana ingaruka ziterwa na dose mukugabanya urugero rwa glucose yamaraso, gutera insuline gusohora, guhagarika ururenda rwa glucagon no kugabanya ubushake bwo kurya mu cyiciro cya 1 kirimo abakorerabushake bafite ubuzima bwiza n’abarwayi bafite diyabete yo mu bwoko bwa 2 (Coskun et al., 2023b, Kwita kuri Diyabete ).Retatrutide yageze kuri 17.5% bivuze kugabanya ibiro mubyumweru 24 ugereranije na placebo mubushakashatsi bwicyiciro cya 2 kirimo abarwayi bafite umubyibuho ukabije kandi bafite ibiro byinshi.Uku kugabanya ibiro kwaherekejwe no kunoza igenzura rya glycemic, umwirondoro wa lipide, imikorere yumwijima nubuzima bwiza (ibisubizo bya Lilly icyiciro cya 2 retatrutide ibisubizo byasohotse mu kinyamakuru The New England Journal of Medicine byerekana ko molekile yiperereza yageze kuri 17.5% bivuze kugabanya ibiro mubyumweru 24 muri abantu bakuru bafite umubyibuho ukabije kandi ufite ibiro byinshi., 2023).Retatrutide nayo yari ifite umwirondoro mwiza wumutekano udafite ibintu bikomeye cyangwa hypoglycemia episode byavuzwe.
Igicapo 1. Retatrutide (LY3437943) ibuza glycated hemoglobine A1c (HbA1c) agaciro (A) hamwe nuburemere bwumubiri (B) mugihe runaka.
. glucagon reseptor agonist mubantu barwaye diyabete yo mu bwoko bwa 2: icyiciro cya 1b, multicentre, impumyi ebyiri, igenzurwa na platbo, itabishaka, igeragezwa ryinshi ryikigereranyo. Lancet. 2022 Ugushyingo 26; 400 (10366): 1869-1881.)
Muri iki gihe Retatrutide iri gutezwa imbere na Eli Lilly na Sosiyete nk'umukandida mushya w’ibiyobyabwenge ku mubyibuho ukabije na diyabete yo mu bwoko bwa 2.Yerekana uburyo bushya bwo kureba ibyakirwa byinshi bigira uruhare muri glucose metabolism hamwe ningufu zingana na molekile imwe.Retatrutide yerekanye imbaraga zidasanzwe mubyitegererezo by'inyamaswa n'ibigeragezo byabantu hamwe numutekano mwiza hamwe no kwihanganira.Iyindi nyigisho irakenewe kugirango hemezwe inyungu zigihe kirekire ningaruka zishobora kubaho mubantu benshi kandi batandukanye.Retatrutide irashobora gutanga uburyo bushya kubarwayi bafite ikibazo cyumubyibuho ukabije na diyabete kandi bakeneye ubuvuzi bwiza.
Turi polypeptide mu Bushinwa, dufite uburambe bwimyaka myinshi mukubyara umusaruro wa polypeptide.Hangzhou Taijia Biotech Co., Ltd. ni uruganda rukora ibikoresho bya polypeptide yabigize umwuga, rushobora gutanga ibihumbi icumi by’ibikoresho fatizo bya polypeptide kandi birashobora no gutegurwa ukurikije ibikenewe.Ubwiza bwibicuruzwa bya polypeptide nibyiza, kandi ubuziranenge bushobora kugera kuri 98%, byamenyekanye nabakoresha kwisi yose. Murakaza neza kutugisha inama.
